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Sildenafil is a potent and selective inhibitor of cGMP-precise phosphodiesterase type 5 (PDE5), which can be chargeable for degradation of cGMP in the corpus cavernosum. The molecular construction of sildenafil is similar to that of cGMP and acts like a competitive binding agent of PDE5 inside the corpus cavernosum, resulting in far more cGMP and e